GW501516 is one of those subjects where the details matter more than the headlines. This page pulls together the background, the mechanisms, and the practical points readers ask about most.
Last reviewed on 2025-10-01. Where a claim depends on a specific study, the study is described rather than over-claimed.
Clinical development stopped after rodent studies showed tumors at multiple sites. Whether those findings predict human cancer risk remains an open question, but they led sponsors to discontinue programs. Human safety data are limited to small, short-term studies that were not designed to assess cancer risk. Reported effects in those studies included changes in blood lipids, but the evidence is insufficient for medical use. Long-term consequences of nonmedical use are not well characterized. Questions about dose, duration, and individual susceptibility remain unresolved.
Cardarine is a common name for GW501516, an investigational compound developed in the 1990s for metabolic conditions. It acts as an agonist at peroxisome proliferator-activated receptor delta, a nuclear receptor involved in lipid and energy metabolism. The compound is frequently mislabeled as a selective androgen receptor modulator, or SARM, but its molecular target is different. GW501516 reached early clinical testing before development was discontinued. It has no approved therapeutic use in any country. The name cardarine is not a formal international nonproprietary name.
Published literature on cardarine includes in vitro assays, rodent experiments, and a small number of human studies. Reports describe effects on exercise capacity and lipid metabolism in animals, while human evidence is sparse. Many online descriptions present the compound as a proven endurance aid, a claim not supported by regulatory approval or large clinical trials. Analytical studies focus on identifying the parent compound and its metabolites in biological samples. Important uncertainties include species differences, dose-response relationships, and the relevance of rodent tumor findings to humans.
Cardarine is the common name for GW501516, a synthetic compound studied as a peroxisome proliferator-activated receptor delta agonist. Researchers developed it to explore treatments for lipid disorders and metabolic conditions. It is not an approved medicine in any country. Early clinical work examined changes in HDL cholesterol and triglycerides, but development was discontinued after animal studies raised concerns about cancer. The compound remains available as a research chemical and appears in discussions of performance enhancement.
| Property | Value | Notes |
|---|---|---|
| Common synonyms | GW501516; GW-1516; endurobol | GW501516 is the research code |
| Drug class | PPARδ agonist | Not a selective androgen receptor modulator |
| Molecular formula | C21H18F3NO3S2 | Established chemical formula |
| Molar mass | 453.5 g/mol | Calculated from the formula |
| Regulatory status | Prohibited in sport; not approved as medicine | Status varies by country |
{\displaystyle k_{\text{eff}}={\frac {(k_{p}-k_{\text{lr}})\phi _{\text{l}}k_{\text{lr}}[2\beta _{l}^{3}-\beta ^{3}+1]+(k_{\text{p}}+2k_{\text{lr}})\beta _{\text{l}}^{3}[\phi _{\text{l}}\beta ^{3}(k_{\text{lr}}-k_{\text{f}})+k_{\text{f}}]}{\beta _{\text{l}}^{3}(k_{\text{p}}+2k_{\text{lr}}-(k_{\text{p}}-k_{\text{lr}})\phi _{\text{l}}[\beta _{\text{l}}^{3}+\beta ^{3}-1])}}}
Flavoring are often added to e-liquids as well as dry smoke blends. There are currently over 7,700 e-liquid flavors available, most have not been laboratory tested for toxicity. There are numerous flavors (e.g., fruit, vanilla, caramel, coffee) of e-liquid available. There are also flavorings that resemble the taste of cigarettes.
deoxyribose Also 2-deoxyribose. A monosaccharide pentose sugar derived from ribose by the replacement of the hydroxyl group attached to the C2 carbon with a single hydrogen atom. D-deoxyribose, in its cyclic ring form, is one of three main functional groups of deoxyribonucleotides and hence of deoxyribonucleic acid (DNA) molecules.
== Role in evolution == By introducing novel genetic qualities to a population of organisms, de novo mutations play a critical role in the combined forces of evolutionary change. However, the weight of genetic diversity generated by mutational change is often considered a generally "weak" evolutionary force. Although the random emergence of mutations alone provides the basis for genetic variation across all organic life, this force must be taken in consideration alongside all evolutionary forces at play. Spontaneous de novo mutations as cataclysmic events of speciation depend on factors introduced by natural selection, genetic flow, and genetic drift. For example, smaller populations with heavy mutational input (high rates of mutation) are prone to increases of genetic variation which lead to speciation in future generations. In contrast, larger populations tend to see lesser effects of newly introduced mutated traits. In these conditions, selective forces diminish the frequency of mutated alleles, which are most often deleterious, over time.
A week later, after meeting Heseltine, the constituency officers issued another letter saying that they regretted how their reply had been construed as criticism. Then came Howe's resignation speech in the Commons on 13 November, in which he launched a strong attack on Thatcher; next morning Heseltine announced his candidacy for the leadership, saying that over 100 MPs had asked him to stand and that he was better placed than Thatcher to lead the Tories to a fourth election victory. During the subsequent leadership election on 20 November, he polled 152 votes (40.9%) in the first round of voting by Conservative MPs, enough to prevent an outright Thatcher victory. (The rules required an incumbent leader to obtain a majority of at least 15% on a first ballot; Thatcher polled 204 votes, equal to 54.8%). Heseltine was thought by many pundits to be on course to beat her in the second ballot as many Conservative MPs were now rumoured to be ready to switch support from Thatcher and only 27 would have had to have done so to give Heseltine the overall majority he would need in the second ballot. With lukewarm support from her Cabinet, most of whom had told her that she could not win and faced with the bitter prospect of a Heseltine premiership, Thatcher withdrew from the contest and announced her resignation on the morning of 22 November, although she continued to serve as prime minister until a new party leader had been chosen.
Sources: en.wikipedia.org
Tyrosine kinases recruited to a receptor following hormone binding are receptor-associated tyrosine kinases and are involved in a number of signaling cascades, in particular those involved in cytokine signaling (but also others, including growth hormone). One such receptor-associated tyrosine kinase is Janus kinase (JAK), many of whose effects are mediated by STAT proteins. (See JAK-STAT pathway.)
The implementation of Trump's plans would add around 4 billion tons of carbon dioxide to the atmosphere by 2030, also having effects on the international level. If the policies do not change further, it would add 15 billion tons by 2040 and 27 billion by 2050. Although the exact calculation is difficult, researchers stated: "Regardless of the precise impact, a second Trump term that successfully dismantles Biden's climate legacy would likely end any global hopes of keeping global warming below 1.5C."
Prominent figures included ethnic Mongol general Ulanhu, who served in high-ranking roles in the Inner Mongolian region and as vice president of China, and Saifuddin Azizi, a Lieutenant General and an ethnic Uyghur who served in the CCP Central Committee. There were a few instances of ethnic distrust within the PLA, with one prominent example being the defection of Margub Iskhakov, an ethnic Muslim Tatar PLA general, to the Soviet Union in the 1960s. However, his defection largely contributed to his disillusion with the failed Great Leap Forward policies, instead of his ethnic background. In modern times, ethnic representation is most visible among junior-ranking officers. Only a few minorities reach the highest-ranking positions.
=== Pest risk analysis === As of 2019 the East African Community considers P. aeruginosa to be a quarantine concern because of the presence of Phaseolus vulgaris–pathogenic strains of P. aeruginosa in Kenya for the rest of the area. A pest risk analysis by the EAC was based on this bacterium's CABI's Crop Protection Compendium listing, following Kaaya & Darji 1989's initial detection in Kenya.
While the first term is simply the zero-point energy, the negative second term describes an attractive force between neighboring oscillators. The same argument can also be extended to a large number of coupled oscillators, and thus skirts issues that would negate the large scale attractive effects of permanent dipoles cancelling through symmetry, in particular. The additive nature of the dispersion effect has another useful consequence. Consider a single such dispersive dipole, referred to as the origin dipole. Since any origin dipole is inherently oriented so as to be attracted to the adjacent dipoles it induces, while the other, more distant dipoles are not correlated with the original dipole by any phase relation (thus on average contributing nothing), there is a net attractive force in a bulk of such particles. When considering identical particles, this is called cohesive force. When discussing adhesion, this theory needs to be converted into terms relating to surfaces. If there is a net attractive energy of cohesion in a bulk of similar molecules, then cleaving this bulk to produce two surfaces will yield surfaces with a dispersive surface energy, since the form of the energy remain the same. This theory provides a basis for the existence of van der Waals forces at the surface, which exist between any molecules having electrons. These forces are easily observed through the spontaneous jumping of smooth surfaces into contact.
Sources: en.wikipedia.org
No. Cardarine is GW501516, a PPARδ agonist, while SARMs act on androgen receptors. The two classes are often grouped in informal discussions despite different mechanisms.
No. It has no approved medical indication in any country. Regulatory agencies have not cleared it for treatment or prevention of any condition.
Early clinical work stopped after rodent carcinogenicity findings. Those animal results raised concerns about long-term human risk, although direct human evidence is lacking. The human relevance of the tumors remains an open scientific question.
Cardarine is a common name for the investigational compound GW501516. It acts as a PPARδ agonist and is not approved for human use. It is prohibited in sport.